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Stroke location, characterization, severity, and outcome in mitral vs aortic valve endocarditis
D J Anderson1, L B Goldstein, W E Wilkinson
1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Neurology
|November 26, 2003
Summary
Infective endocarditis (IE) patients have a 9.6% stroke incidence, with mitral valve endocarditis posing a higher risk. Over half of stroke patients with IE died within one year.
Area of Science:
- Cardiology
- Neurology
- Infectious Diseases
Background:
- Infective endocarditis (IE) is a serious infection affecting heart valves.
- Stroke is a known complication of IE, but its incidence and risk factors require further characterization.
Purpose of the Study:
- To determine the incidence and clinical features of stroke in patients with infective endocarditis.
- To compare stroke risk between different types of valvular endocarditis.
Main Methods:
- Retrospective review of 707 patients with definite or possible IE from 1984 to 1999.
- Strict definitions were used to confirm and classify strokes by type, pathophysiology, vascular territory, and severity.
- Mortality rates were assessed at initial hospitalization and 12 months post-admission.
Main Results:
- Stroke occurred in 9.6% of IE patients (68/707).
- Mitral valve endocarditis (MVE) patients had a significantly higher risk of stroke (17%) compared to aortic valve endocarditis (AVE) patients (9%).
- Fifty-two percent of IE patients who experienced a stroke died within one year.
Conclusions:
- The incidence of stroke in IE is lower than previously reported.
- Mitral valve endocarditis is associated with a greater risk of stroke compared to aortic valve endocarditis.
- Stroke in IE carries a high mortality rate, with over half of affected patients dying within a year.
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