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Updated: Aug 30, 2026

Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
Published on: April 21, 2023
Abnormal sensorimotor integration is related to disease severity in Parkinson's disease: a TMS study
Stefano Tamburin1, Antonio Fiaschi, Domenico Idone
1Department of Neurological Sciences and Vision, Section of Neurological Rehabilitation, University of Verona, Verona, Italy. stefano.tamburin@mail.univr.it
Abstract:
Hyperexcitability of the motor system has been reported in Parkinson's disease (PD). We evaluate how cutaneous afferents modulate motor excitability in PD patients and whether abnormal modulation is correlated to parkinsonian symptoms. Digital stimulation causes abnormal enhancement of motor responses in patients. This effect may be one of the features of motor hyperexcitability in PD. Cutaneomotor hyperexcitability correlates with clinical scores, suggesting that abnormal processing of cutaneous inputs might contribute to the pathogenesis of parkinsonian symptoms.
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