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Related Experiment Videos

Lactobacilli, anticarcinogenic activities and human intestinal microflora.

A Lidbeck1, C E Nord, J A Gustafsson

  • 1Department of Microbiology, Huddinge University Hospital, Karolinska Institute, Sweden.

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
|August 1, 1992
PubMed
Summary

Lactobacillus acidophilus supplements may reduce colon cancer risk. Studies show these probiotics increase beneficial gut bacteria and decrease cancer-promoting compounds in the digestive tract.

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Oncology

Background:

  • Lactobacilli are normal human microflora, aiding gut health and pathogen resistance.
  • Dietary supplements like Lactobacillus acidophilus are used for gastrointestinal issues.
  • Certain lactobacilli strains are investigated for potential anticarcinogenic effects.

Purpose of the Study:

  • To investigate the anticarcinogenic potential of Lactobacillus acidophilus.
  • To evaluate the effects of L. acidophilus on bacterial enzymes and bile acids in the colon.
  • To assess the role of L. acidophilus in absorbing food mutagens.

Main Methods:

  • Supplementation with Lactobacillus acidophilus in rats and humans.
  • Analysis of faecal bile acids and bacterial enzyme levels.

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  • In vitro studies on mutagen absorption by lactobacilli.
  • Human studies involving L. acidophilus intake and mutagen excretion after fried meat consumption.

    • Main Results:

    • L. acidophilus supplementation decreased bacterial enzyme and bile acid levels in rats and humans.
    • Colon cancer patients consuming L. acidophilus fermented milk showed increased intestinal lactobacilli and calcium intake.
    • Lactobacilli demonstrated in vitro ability to absorb cooked food mutagens.
    • Human intake of L. acidophilus reduced mutagen excretion after consuming fried meat.

    Conclusions:

    • Lactobacillus acidophilus may lower colon cancer risk through various mechanisms.
    • Probiotic supplementation with L. acidophilus shows promise in reducing cancer risk factors.
    • Further research into specific lactobacilli strains and their anticarcinogenic mechanisms is warranted.