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Cellular consequences of transthyretin deposition
1Instituto de Biologia Molecular e Celular, Instituto de Ci ncias Biom dicas Abel Salazar, University of Porto, Portugal. mjsaraiv@ibmc.up.pt
Abstract:
Mutant forms of transthyretin (TTR) deposit in tissues of patients presenting with familial amyloidotic polyneuropathy (FAP). The cellular consequences of tissue TTR deposition have only been addressed recently and are summarized here. Inflammatory and oxidative stress pathways are triggered by fibrillar and non-fibrillar TTR deposits, a fact to take into account in future forms of FAP treatment.