Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue characterization by quantitative optical imaging methods.

Amir H Gandjbakhche1, Victor Chernomordik, David Hattery

  • 1National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. amir@helix.nih.gov

Technology in Cancer Research & Treatment
|December 4, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polarizer-assisted pupillometry through closed eyelids, overcoming pupil position dependence.

Journal of biomedical optics·2026
Same author

Malaria RDT (mRDT) interpretation accuracy by frontline health workers compared to AI in Kano state, Nigeria.

BMC digital health·2025
Same author

From Traditional to Cutting-Edge: A Review of Fetal Well-Being Assessment Techniques.

IEEE transactions on bio-medical engineering·2025
Same author

Label-Free Metabolic Imaging In Vivo by Two-Photon Fluorescence Lifetime Endomicroscopy.

ACS photonics·2024
Same author

Healthcare delivery in the arctic-telehealth prospects.

International journal of circumpolar health·2024
Same author

Touchless short-wave infrared imaging for dynamic rapid pupillometry and gaze estimation in closed eyes.

Communications medicine·2024
Same journal

Proteomics in Acute Myeloid Leukemia: Current Applications in Precision Medicine and Targeted Immunotherapy.

Technology in cancer research & treatment·2026
Same journal

EML4-ALK in Non-small Cell Lung Cancer: Molecular Mechanisms and Targeted Therapies.

Technology in cancer research & treatment·2026
Same journal

Developing and Validating a Risk Model for Severe Bone Marrow Suppression in Esophageal Cancer Treated with Radiotherapy or Chemoradiotherapy: A Retrospective Cohort Study.

Technology in cancer research & treatment·2026
Same journal

A Novel Adjustable Tandem and Ring Applicator for Improved Dosimetry in Cervical Cancer HDR Brachytherapy.

Technology in cancer research & treatment·2026
Same journal

Construction and Clinical Validation of a Colorectal Cancer OPISV Prognostic Model Integrating EPHB2 and ZNF346: Potential Regulatory Role of the Axon Guidance Pathway.

Technology in cancer research & treatment·2026
Same journal

Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Melanoma: A Systematic Review of Phase One Clinical Trials.

Technology in cancer research & treatment·2026
See all related articles

New optical methods overcome deep-tissue scattering for advanced medical diagnosis. These techniques enable functional characterization of tumors and monitoring of immune responses using fluorescence imaging.

Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Cancer Diagnostics

Background:

  • Optical methods offer high biomolecular specificity, valuable in microscopy and histopathology.
  • Deep tissue optical imaging is challenged by multiple-scattering, limiting signal quality.
  • Advancements in stochastic methods and fluorescence imaging are expanding optical techniques for deep tissue applications.

Purpose of the Study:

  • To develop and apply advanced optical methods for functional characterization of tumors in breast tissue.
  • To explore fluorescence-based techniques for detecting and monitoring tumor status and immune response.
  • To overcome the limitations of light scattering in deep tissues for improved medical diagnosis.

Main Methods:

  • Quantifying anomalous site parameters in breast tissue using novel optical methods.

Related Experiment Videos

  • Developing continuous-wave (CW) fluorescence imaging for tumor site localization.
  • Utilizing time-resolved fluorescence data and probe lifetime sensitivity to metabolic parameters (pH, temperature) for functional tumor information.

    • Main Results:

    • Demonstrated a method for quantifying parameters of anomalous sites in breast tissue for tumor characterization.
    • Developed fluorescence-based approaches for tumor detection and monitoring.
    • Established techniques for localizing tumor sites and obtaining functional insights using optical probes.

    Conclusions:

    • Advanced optical techniques, including stochastic methods and fluorescence imaging, show promise for deep tissue medical diagnosis.
    • These methods enable functional characterization of tumors and monitoring of their status and the associated immune response.
    • The developed techniques extend the utility of optical methods for in vivo imaging and cancer diagnostics.