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Cyclooxygenase inhibition in cancer prevention and treatment

William F Anderson1, Asad Umar, Ernest T Hawk

  • 1Gastrointestinal & Other Cancers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, EPN, Room 2141, 6130 Executive Boulevard, Bethesda, MD 20892-7317, USA.

Expert Opinion on Pharmacotherapy
|December 4, 2003
PubMed

Insights

Cyclooxygenase-2 (COX-2) is a key target for cancer prevention and therapy. Modulating COX-2 with inhibitors like NSAIDs and COXIBs offers therapeutic opportunities, though safety and economic factors require consideration.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Cyclooxygenase-2 (COX-2) is overexpressed during cancer development.
  • COX-2 plays a role in tumor initiation and promotion.
  • Targeting COX-2 presents opportunities for cancer intervention.

Purpose of the Study:

  • To review the role of COX-2 in cancer.
  • To discuss COX modulation strategies using NSAIDs and COXIBs.
  • To examine pharmacoeconomic and safety aspects of COX inhibitors.

Main Methods:

  • Literature review of studies on COX-2 and cancer.
  • Analysis of non-specific and COX-2 selective inhibitors.
  • Discussion of pharmacoeconomic and safety data.

Main Results:

  • COX-2 is a viable molecular target for cancer prevention and therapy.
  • Non-specific NSAIDs and selective COXIBs are key modulators.
  • Safety and economic considerations are crucial for clinical application.

Conclusions:

  • COX-2 inhibition is a promising strategy for cancer intervention.
  • Careful consideration of NSAID and COXIB use, including safety and cost, is essential.
  • Further research into optimal COX-2 targeting is warranted.

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