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Sexual dysfunction with psychotropic drugs.

Michael Gitlin1

  • 1Department of Psychiatry, UCLA School of Medicine, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA. mgitlin@mednet.ucla.edu

Expert Opinion on Pharmacotherapy
|December 4, 2003
PubMed
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Psychotropic medications like antidepressants and antipsychotics can cause sexual dysfunction. Treatment options for this side effect are limited, but some antidotes exist.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Sexual Medicine

Background:

  • Sexual dysfunction is a common and significant side effect of psychotropic medications.
  • The prevalence of these side effects is challenging to determine accurately due to various influencing factors.

Purpose of the Study:

  • To review the impact of psychotropic medications on sexual function.
  • To discuss the mechanisms and prevalence of medication-induced sexual dysfunction.
  • To explore current treatment strategies.

Main Methods:

  • Literature review of psychotropic medications and their sexual side effects.
  • Analysis of factors influencing prevalence rates.
  • Summary of treatment approaches and potential antidotes.

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Main Results:

  • Antidepressants with strong serotonergic activity and antipsychotics with high D2 blockade (leading to increased prolactin) are associated with higher rates of sexual dysfunction.
  • Effective treatment strategies remain underdeveloped.

Conclusions:

  • Sexual side effects are a considerable issue with psychotropic drug use.
  • Bupropion, buspirone, and sildenafil show promise as antidotes for antidepressant-induced sexual dysfunction.