Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrating functional genomics data.

P Kemmeren1, F C P Holstege

  • 1Genomics Lab, Division of Biomedical Genetics, UMC Utrecht, PO Box 85060, 3508 AB Utrecht, The Netherlands.

Biochemical Society Transactions
|December 4, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intestinal LKB1 Loss Drives a Premalignant Program Along the Serrated Cancer Pathway.

Gastroenterology·2025
Same author

High-resolution genetic mapping of mammalian motor activity levels in mice.

Genes, brain, and behavior·2008
Same author

cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype.

Animal genetics·2008
Same author

A microarray screen for novel candidate genes in coeliac disease pathogenesis.

Gut·2004
Same journal

Beyond the scaffold: extracellular matrix uptake in breast cancer.

Biochemical Society transactions·2026
Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026
Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026
Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026
Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026
Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026
See all related articles

Integrating high-throughput genomic data improves functional annotation accuracy. This approach assesses data quality, prioritizes hypotheses, and refines genome annotations for better biological insights.

Area of Science:

  • Genomics
  • Bioinformatics
  • Functional Annotation

Background:

  • Accurate functional annotation of sequenced genomes remains a significant challenge in genomics.
  • High-throughput data offers potential for enhanced functional genome annotation.

Purpose of the Study:

  • To integrate diverse high-throughput datasets for improved functional genome annotation.
  • To develop a framework for assessing data quality and prioritizing research hypotheses.

Main Methods:

  • Data integration strategies for high-throughput genomic datasets.
  • Quality assessment metrics for functional annotation data.
  • Hypothesis prioritization algorithms for biological research.

Main Results:

Related Experiment Videos

  • Demonstrated improvement in the quality and scope of functional annotations.
  • Successful prioritization of key biological hypotheses based on integrated data.
  • Enhanced ability to extend and refine existing genomic annotations.

Conclusions:

  • Integrated high-throughput data is crucial for advancing functional genomics.
  • A systematic approach to data integration and quality assessment is necessary.
  • This methodology significantly improves genome annotation reliability and utility.