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Updated: Aug 30, 2026

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
Published on: April 2, 2021
Outcome of zone 1 retinopathy of prematurity
Michael O'Keefe1, Bernadette Lanigan, Vernon W Long
1National Children's Eye Centre, Children's University Hospital, Temple Street, Dublin 1, Ireland. tchopth@indigo.ie
Purpose:
To describe the outcome in a series of patients with pre-threshold and threshold zone 1 retinopathy of prematurity.
Methods:
We performed a retrospective analysis of 12 babies, 24 eyes, with zone 1 retinopathy of prematurity, treated between 1992 and 2002 with diode laser treatment.
Results:
Ten out of the 12 babies had an unfavourable outcome. The only patients with successful anatomical outcomes were those treated before threshold disease occurred. All babies had developmental delay or neurological disability.
Conclusion:
Zone 1 retinopathy of prematurity has a poor anatomical and visual prognosis and many of the babies in our study had developmental delay and neurological disability. Earlier treatment may improve the visual outcome.

