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Treatment of squamous cell carcinoma with intralesional 5-Fluorouracil
Lisa G Morse1, Christina Kendrick, Deirdre Hooper
1Department of Dermatology, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA.
Background:
5-Fluorouracil (5-FU) has been used topically and intralesionally to treat lesions related to squamous cell carcinoma (SCC) such as actinic keratosis, Bowen's disease, and keratoacanthoma.
Objective:
We sought to determine whether intralesional 5-FU might be effective in treating a patient with SCC.
Methods:
A patient with SCC at the junction of the right alar crease and right nasolabial fold was treated with eight weekly injections of 5-FU, with doses ranging from 0.8 to 2.4 mL.
Results:
A repeat biopsy after the eighth treatment showed total clearance of the cancer, and the patient has remained free of recurrence during a 5-month follow-up period.
Conclusion:
This modality may provide patients with SCC in cosmetically important locations or in areas that require complex surgery the advantage of a nonsurgical cure.
