Related Experiment Video
Updated: Aug 30, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Adenoidectomy during early life and the risk of asthma
Petri S Mattila1, Sari Hammarén-Malmi, Jussi Tarkkanen
1Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland. petri.mattila@hus.fi
Insights
Children who undergo adenoidectomy (surgical removal of the adenoids) before age 4 face an increased risk of developing asthma. This association may stem from underlying factors common to both conditions.
Area of Science:
- Pediatric Medicine
- Otolaryngology
- Allergology
Background:
- Adenoidectomy is a common procedure in children, often performed for conditions like glue ear or recurrent otitis media.
- A potential link between adenoidectomy and the subsequent development of asthma has been observed but requires further investigation.
Purpose of the Study:
- To evaluate the association between undergoing an adenoidectomy and the risk of developing asthma in pediatric populations.
- To explore if the timing of adenoidectomy influences asthma risk.
Main Methods:
- Two distinct surveys were conducted: a nationwide questionnaire study (Survey A) and a hospital discharge record analysis (Survey B).
- Survey A involved 483 participants, while Survey B analyzed records of 1616 children who had adenoidectomies and 161 controls.
- Asthma diagnoses were confirmed via national asthma registers in Survey B.
Main Results:
- Survey A indicated that adenoidectomy before age 4 was linked to a higher risk of asthma (OR 3.19) and animal dust allergy (OR 2.50).
- Survey B revealed a significant association between early-age adenoidectomy and an increased risk of asthma (OR 6.74).
- The risk of asthma was notably higher in children who underwent adenoidectomy due to recurrent otitis media.
Conclusions:
- A significant association exists between adenoidectomy and an increased risk of asthma in children.
- The findings suggest a potential underlying predisposition to both recurrent otitis media and asthma, influencing the decision for adenoidectomy.
Abstract:
The objective of the study was to evaluate the risk of asthma in children who had undergone an adenoidectomy, an operation frequently performed on children with glue ear or recurrent otitis media. Two surveys were carried out, a nation-wide questionnaire returned by 483 individuals (survey A) and a survey of hospital discharge records involving 1616 children who had undergone an adenoidectomy and 161 control children who had undergone probing of the nasolacrimal duct due to congenital obstruction (survey B). The questionnaire (survey A) showed that an adenoidectomy before the age of 4 years was associated with asthma (OR 3.19, 95% CI 1.25; 8.13) and with allergy to animal dust (OR 2.50, 95% CI 1.27; 4.95). In survey B, asthma diagnosis was retrieved from the national asthma register. It showed also that adenoidectomy at an early age was associated with an increased risk of asthma (OR 6.74, 95% CI 2.99; 15.2). There was an association between asthma and adenoidectomy, even before adenoidectomy had actually been performed. The risk of asthma was highest among children who had had adenoidectomy because of recurrent otitis media. The observed association between an adenoidectomy and asthma may be explained by an underlying factor predisposing to both recurrent otitis media and asthma.
Related Concept Videos
Asthma I: Introduction
Asthma-I: Introduction
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications
Classification of Asthma
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by anesthetizing...