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A Periprosthetic Joint Candida albicans Infection Model in Mouse
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A Periprosthetic Joint Candida albicans Infection Model in Mouse

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Prosthetic joint infections with osteomyelitis due to Candida albicans

K Lerch1, T Kalteis, T Schubert

  • 1Department of Orthopedic Surgery, Bad Abbach, University of Regensburg, Germany. klaus.lerch@klinik.uni-regensburg.de

Mycoses
|December 4, 2003
PubMed

Insights

This case study shows that higher fluconazole doses (800 mg daily) combined with surgical debridement successfully treated a severe knee joint infection caused by Staphylococcus aureus and Candida albicans after total knee replacement.

Area of Science:

  • Infectious Diseases
  • Orthopedic Surgery
  • Mycology

Background:

  • A 78-year-old woman developed a severe soft tissue and bone infection in her left knee three years post-total knee-joint replacement.
  • The infection occurred without evidence of endoprosthesis loosening.

Observation:

  • Cultures identified Staphylococcus aureus and Candida albicans.
  • Microscopic examination revealed microabscesses and yeast cells within the bone marrow and fibrous tissue.

Findings:

  • Standard fluconazole therapy (400 mg daily) showed no reduction in yeast cells.
  • Higher fluconazole doses (800 mg daily) combined with surgical debridement eradicated the fungal infection.

Implications:

  • Aggressive antifungal treatment and surgical intervention are crucial for managing complex prosthetic joint infections.
  • This case highlights the need for tailored treatment strategies for co-infections involving bacteria and fungi.

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