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Skin infection caused by Scedosporium apiospermum

A Karaarslan1, S Arikan, F Karaarslan

  • 1Department of Microbiology and Clinical Microbiology, Ankara University Medical School, Ankara, Turkey. karaars@medicine.ankara.edu.tr

Mycoses
|December 3, 2003
PubMed

Insights

A rare Scedosporium apiospermum skin infection in a woman's feet was successfully treated. Oral terbinafine and topical clotrimazole proved effective against this fungal infection.

Area of Science:

  • Medical Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Scedosporium apiospermum is an opportunistic mold that can cause infections, particularly in immunocompromised individuals.
  • Cutaneous infections, especially in the interdigital spaces of the feet, are less common but can be challenging to treat.

Observation:

  • A case study detailing a woman diagnosed with a Scedosporium apiospermum infection affecting the skin between her toes.
  • The isolated Scedosporium apiospermum demonstrated varying minimum inhibitory concentrations (MICs) against antifungal agents.

Findings:

  • The minimum inhibitory concentrations (MICs) for itraconazole, amphotericin B, and terbinafine were determined to be 1 µg/mL, 8 µg/mL, and 16 µg/mL, respectively, after 48 hours of incubation.
  • The patient achieved successful treatment outcomes using a combination of oral terbinafine and topical clotrimazole.

Implications:

  • This case highlights the potential for Scedosporium apiospermum to cause interdigital skin infections.
  • The findings suggest that terbinafine, despite a higher MIC in vitro, can be an effective treatment option when combined with topical agents.
  • Further research into optimal treatment strategies for Scedosporium apiospermum cutaneous infections is warranted.

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