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Tomatoes have natural anti-thrombotic effects
1Laboratory of Physiology, Faculty of Nutrition and High Technology Research Centre, Kobe Gakuin University, Kobe, Japan. yamamoto@nutr.kobegakuin.ac.jp
The British Journal of Nutrition
|December 4, 2003
Summary
Tomato extracts show significant anti-thrombotic effects, with one variety inhibiting thrombus formation and promoting clot breakdown. This research highlights tomatoes as a potential dietary approach for preventing arterial thrombotic diseases.
Area of Science:
- Cardiovascular Research
- Nutritional Science
- Pharmacology
Background:
- Arterial thrombotic diseases are a major health concern in developed nations.
- Dietary factors, including an inappropriate diet, are significant risk factors for thrombotic events.
- An anti-thrombotic diet presents a potential strategy for disease prevention.
Purpose of the Study:
- To evaluate the anti-thrombotic effects of tomato extracts.
- To identify specific tomato varieties possessing anti-thrombotic properties.
- To assess the efficacy of tomato extracts in preventing arterial thrombosis.
Main Methods:
- In vitro assessment of anti-thrombotic potential using a shear-induced platelet-function test (haemostatometry).
- In vivo evaluation of promising tomato extracts in a laser-induced thrombosis model in mice.
- Analysis of thrombus formation inhibition and thrombolytic effects.
Main Results:
- One tomato variety (KG99-4) demonstrated significant anti-thrombotic activity in both in vitro and in vivo models.
- KG99-4 extract effectively inhibited the formation of platelet-rich thrombi.
- The KG99-4 extract also exhibited a notable thrombolytic effect, aiding in clot dissolution.
Conclusions:
- Haemostatometry is a reliable method for detecting and characterizing the anti-thrombotic potential of fruits and vegetables.
- Tomato variety KG99-4 possesses significant anti-thrombotic and thrombolytic properties.
- Dietary intake of specific tomato varieties may offer a practical approach to preventing arterial thrombotic diseases.
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