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[Age-specific reference ranges for serum prostate-specific antigen in Chinese men].
Ming-zhu Wang1, Zhong-wei Gao, Da-lin He
1Institute of Urology of Xi'an Jiaotong University, Xi'an 710061, China.
Zhonghua Yi Xue Za Zhi
|December 3, 2003
Summary
This study establishes age-specific reference ranges for prostate-specific antigen (PSA) in Chinese men, revealing significantly lower levels compared to other ethnicities. These findings are crucial for accurate prostate cancer screening in this population.
Area of Science:
- Urology
- Biochemistry
- Public Health
Background:
- Prostate-specific antigen (PSA) is a key biomarker for prostate health.
- Establishing accurate reference ranges is vital for effective screening and diagnosis.
- Existing PSA reference ranges may not be universally applicable across diverse ethnic groups.
Purpose of the Study:
- To determine age-specific reference ranges for serum PSA in Chinese men.
- To compare these ranges with those of other ethnic populations.
- To inform clinical practice regarding PSA screening in Chinese males.
Main Methods:
- Serum total PSA (tPSA) and free PSA (fPSA) were measured using enzyme-linked immunosorbent assay (ELISA).
- The fPSA/tPSA ratio was calculated for 1,096 healthy Chinese men aged 23-85.
- Simple linear regression analyzed the relationship between age and PSA indexes.
Main Results:
- Age-specific reference ranges (95th percentile) for serum PSA in Chinese men were established.
- PSA levels showed a direct correlation with age.
- Chinese men exhibited lower age-specific PSA reference ranges compared to white, black, Japanese, and Korean men.
Conclusions:
- Significantly lower age-specific PSA reference ranges are identified for Chinese men.
- These findings underscore the importance of ethnicity-specific ranges for serum PSA interpretation.
- Accurate PSA reference ranges are essential for the early detection of prostate abnormalities in Chinese men.