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Surgical approaches and intestinal transplantation
Enrico Benedetti1, Fabrizio Panaro, Mark Holterman
1University of Illinois at chicago, 1Division of Transplantation, 840 S. Wood St., Chicago, IL 60612, USA. enrico@uic.edu
Best Practice & Research. Clinical Gastroenterology
|December 4, 2003
Summary
Intestinal transplantation is a life-saving option for patients with intestinal failure, offering excellent rehabilitation. Advances in immunosuppression and care have made this complex surgery a clinical reality.
Area of Science:
- Gastroenterology and Hepatology
- Transplant Surgery
Background:
- Short-bowel syndrome treatment traditionally focused on mechanical obstruction or intestinal expansion.
- Bacterial overgrowth syndrome is a common complication addressed by surgical interventions.
Purpose of the Study:
- To review the evolution and current status of intestinal transplantation.
- To highlight advances in immunosuppression, preservation, monitoring, and critical care for intestinal transplantation.
Main Methods:
- Historical overview of intestinal transplantation development.
- Discussion of current indications and outcomes based on clinical practice.
Main Results:
- Intestinal transplantation has evolved significantly since its introduction in 1964.
- Modern immunosuppressive regimens and improved critical care have transformed outcomes.
- Successful cases demonstrate excellent patient rehabilitation.
Conclusions:
- Intestinal transplantation is now a viable, life-saving procedure for select patients with intestinal failure.
- Indications include life-threatening complications from underlying disease or total parenteral nutrition (TPN).
- Ongoing advancements continue to improve the success rates and patient recovery.