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Experimental approaches: dietary and hormone therapy
1Department of Medicine CA-2121, Section of Gastroenterology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100, Copenhagen, Denmark. bekker@dadlnet.dk
Best Practice & Research. Clinical Gastroenterology
|December 4, 2003
Summary
Patients with intestinal failure need parenteral support. This chapter reviews dietary and hormone therapies, including growth hormone and glucagon-like peptide 2, to improve intestinal adaptation and reduce reliance on IV nutrition.
Area of Science:
- Gastroenterology
- Endocrinology
- Nutritional Science
Background:
- Intestinal failure necessitates parenteral support for nutritional balance.
- Optimizing remnant intestinal function is key to improving quality of life.
Purpose of the Study:
- To define recommendations for evaluating absorptive capacity in intestinal failure.
- To present evidence on dietary and hormone therapy for intestinal adaptation.
Main Methods:
- Review of dietary strategies, including carbohydrate:fat ratios in short-bowel syndrome (SBS).
- Evaluation of growth hormone and glucagon-like peptide 2 (GLP-2) for promoting intestinal adaptation.
Main Results:
- Dietary modifications impact nutrient absorption in SBS patients.
- Growth hormone and GLP-2 show potential in enhancing intestinal adaptation.
Conclusions:
- Therapeutic strategies aim to maximize remnant intestinal function.
- Reducing parenteral support dependence improves patient quality of life.