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No evidence for a seriously increased malignancy risk in LGI1-caused epilepsy
Eylert Brodtkorb1, Karl O Nakken, Ortrud K Steinlein
1Department of Neurology, St. Olavs's Hospital, Trondheim, Norway.
Epilepsy Research
|December 4, 2003
Abstract:
The Leucine-rich Glioma Inactivated-1 (LGI1) gene is supposed to be a tumor suppressor gene involved in glial tumors. Mutations in this gene were recently found to cause autosomal dominant lateral temporal lobe epilepsy (ADLTE). We have now analysed the comorbidity in a large Norwegian ADLTE family. No evidence was found that LGI1 is a high-penetrance tumor suppressor gene associated with a serious risk for malignancies in ADLTE families.