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Updated: Aug 30, 2026

Skeletal Muscle Gender Dimorphism from Proteomics
Published on: December 14, 2011
At the crossroads of skeletal responses to estrogen and exercise
1Rheumatology Unit, Bristol Royal Infirmary, BS2 8HW, Bristol, UK. Jon.Tobias@bristol.ac.uk
Abstract:
The recent observation that mice deficient in estrogen receptor alpha (ERalpha) have an impaired response to mechanical strain suggests that ERalpha plays an important role in mediating the response of the skeleton to mechanical loading as well as to estrogen. In view of previous findings that estrogen deficiency leads to a fall in ERalpha numbers, postmenopausal bone loss might result from the impaired response of bone to mechanical strain caused by deficient ERalpha signalling.
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