Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of serotonin receptor 2C in schizophrenia brains identified by high-resolution mRNA expression analysis.

Anja Castensson1, Lina Emilsson, Rolf Sundberg

  • 1Department of Evolutionary Biology, Uppsala University, Uppsala, Sweden

Biological Psychiatry
|December 4, 2003
PubMed
Summary

This study found two genes, monoamine oxidase B and serotonin receptor 2C, are differentially expressed in schizophrenia brains. Serotonin receptor 2C alterations are relevant for developing new antipsychotic drugs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-biased gene expression during neural differentiation of human embryonic stem cells.

Frontiers in cell and developmental biology·2024
Same author

DNA methylation in canine brains is related to domestication and dog-breed formation.

PloS one·2020
Same author

Increased Expression of Y-Encoded Demethylases During Differentiation of Human Male Neural Stem Cells.

Stem cells and development·2020
Same author

Novel Y-Chromosome Long Non-Coding RNAs Expressed in Human Male CNS During Early Development.

Frontiers in genetics·2019
Same author

Gene Expression of Quaking in Sporadic Alzheimer's Disease Patients is Both Upregulated and Related to Expression Levels of Genes Involved in Amyloid Plaque and Neurofibrillary Tangle Formation.

Journal of Alzheimer's disease : JAD·2016
Same author

Spatial sexual dimorphism of X and Y homolog gene expression in the human central nervous system during early male development.

Biology of sex differences·2016

Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • RNA expression profiling aids in identifying disease susceptibility genes and drug targets.
  • Investigated messenger RNA expression of 16 candidate genes in 55 schizophrenia patients and 55 controls.
  • Largest sample size to date for identifying differentially expressed genes in schizophrenia brains.

Purpose of the Study:

  • To identify genes with altered expression in schizophrenia.
  • To explore potential genetic markers for schizophrenia development.
  • To evaluate candidate gene targets for novel drug development.

Main Methods:

  • Utilized sensitive real-time polymerase chain reaction methodology.
  • Employed a novel statistical approach, including a linear model of analysis of covariance.

Related Experiment Videos

  • Analyzed messenger RNA expression levels in brain samples.

    • Main Results:

    • Monoamine oxidase B expression was significantly increased in schizophrenia brains (p =.001).
    • Serotonin receptor 2C expression was significantly decreased in schizophrenia brains (p =.001).
    • Other previously proposed candidate genes showed no differential expression.

    Conclusions:

    • Differential expression of serotonin receptor 2C is significant for developing novel atypical antipsychotic medications.
    • The study's strategy is valuable for testing hypotheses on disease development.
    • Findings contribute to understanding schizophrenia pathogenesis.