Related Experiment Video
Updated: Jul 8, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Haemoglobin-related mortality in patients undergoing percutaneous coronary interventions
Holger Reinecke1, Torsten Trey, Jürgen Wellmann
1Medizinische Klinik und Poliklinik C (Department of Cardiology and Angiology), Hospital of the University of Münster, Münster, Germany. reinech@uni-muenster.de
Insights
Patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI) who have anaemia face significantly reduced long-term survival. This highlights the need for managing anaemia in these patients.
Area of Science:
- Cardiology
- Hematology
Background:
- Anaemia is increasingly recognized as a risk factor for cardiovascular disease.
- The impact of anaemia on survival in patients with established coronary heart disease (CHD) after interventions remains unclear.
Purpose of the Study:
- To investigate the association between haemoglobin levels and long-term outcomes in patients undergoing percutaneous coronary interventions (PCI).
Main Methods:
- Retrospective cohort study of male patients undergoing elective PCI (1998-1999).
- Patients categorized into quintiles based on baseline haemoglobin.
- Analysis of in-hospital and long-term mortality, with a median follow-up of 697 days.
Main Results:
- High angiographic success and low in-hospital mortality across all haemoglobin quintiles.
- Patients in the lowest haemoglobin quintile (
- A U-shaped relationship observed between mortality and haemoglobin levels; lowest quintile showed a 4.09-fold increased adjusted risk of death.
Conclusions:
- Anaemia is linked to substantially decreased survival in patients with CHD following elective PCI.
- Development of management strategies for anaemic patients with CHD undergoing PCI is warranted given the prevalence of anaemia.
Aims:
It has recently been proposed that anaemia is an independent risk factor for development of cardiovascular disease in the general population. The impact of anaemia on long-term survival of patients with manifest coronary heart disease (CHD) has not been assessed so far. In this study, we examined the influence of haemoglobin concentrations on the outcome after percutaneous coronary interventions (PCI).
Methods And Results:
In a retrospective cohort study, we analysed in-hospital and long-term mortality in all male patients admitted to our institution for elective PCI from 1998 to 1999. In 689 cases, complete follow-up information could be obtained (98.4%). Depending on their baseline haemoglobin, patients were divided in quintiles. In all subgroups, angiographic success after PCI (90-94%) was comparably high and in-hospital mortality was low (0-0.7%). During follow-up (median 697 days), patients in the lowest haemoglobin quintile (
Conclusions:
These results indicate that anaemia is associated with markedly reduced survival in patients with CHD after elective PCI. Since PCI is a common intervention and anaemia is a frequent condition in the general population, strategies for the management of anaemic PCI patients and treatment of anaemic patients with CHD should be developed.
More Related Videos
06:10Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
Published on: June 12, 2021
05:41Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control
Published on: December 16, 2022
Related Concept Videos
01:28Cardiac Catheterization I: Pre-Procedure Overview
01:21Cardiac Catheterization II: Right Heart Catheterization
01:28Acute Coronary Syndrome IV: Interprofessional Care
01:29Pulmonary Embolism I: Introduction
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care