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DAPI derivative: a fluorescent DNA dye that can be covalently attached to biomolecules
Min Li1, Robert S Wu, Jane S C Tsai
1Roche Diagnostics Corporation, 9115 Hague Road, Indianapolis, IN 46250, USA. minli88@att.net
Bioorganic & Medicinal Chemistry Letters
|December 4, 2003
Abstract:
The preparation of a DAPI (4',6-diamidino-2-phenylindole) derivative is described. The resulting derivative retains the fluorogenic property upon binding to double-stranded DNA. Its ability for bioconjugation through amide linkage is demonstrated.