Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metal-induced apoptosis: mechanisms.

Marisa D Pulido1, Alan R Parrish

  • 1Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A&M University System Health Science Center, College Station, TX 77843-1114, USA.

Mutation Research
|December 4, 2003
PubMed
Summary

This review details how metals like arsenic and cadmium trigger apoptosis, or programmed cell death. Understanding these metal-induced apoptosis pathways is key to cancer research and developing new cancer treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lead Decreases Bone Morphogenetic Protein-7 (BMP-7) Expression and Increases Renal Cell Carcinoma Growth in a Sex-Divergent Manner.

International journal of molecular sciences·2024
Same author

Abdominal Aortic Endothelial Dysfunction Occurs in Female Mice With Dextran Sodium Sulfate-Induced Chronic Colitis Independently of Reactive Oxygen Species Formation.

Frontiers in cardiovascular medicine·2022
Same author

The renoprotective effects of soy protein in the aging rat kidney.

Medical research archives·2021
Same author

Insulin resistance, cardiovascular stiffening and cardiovascular disease.

Metabolism: clinical and experimental·2021
Same author

Cadmium and Lead Decrease Cell-Cell Aggregation and Increase Migration and Invasion in Renca Mouse Renal Cell Carcinoma Cells.

International journal of molecular sciences·2019
Same author

The impact of aging on epithelial barriers.

Tissue barriers·2017

Area of Science:

  • Cell Biology
  • Toxicology
  • Carcinogenesis

Background:

  • Apoptosis (programmed cell death) mechanisms have been intensely studied.
  • Metal toxicity is a significant environmental and health concern.
  • Apoptosis plays a crucial role in development and disease.

Purpose of the Study:

  • To review current knowledge on apoptosis pathways induced by metals.
  • To focus on established and potential human carcinogens.
  • To link metal-induced apoptosis to carcinogenesis and chemotherapy.

Main Methods:

  • Literature review of studies on metal-induced apoptosis.
  • Analysis of signaling pathways mediating metal toxicity.
  • Synthesis of data on carcinogenicity and therapeutic potential of metals.

Related Experiment Videos

Main Results:

  • Metals like arsenic, cadmium, chromium, nickel, and beryllium initiate specific apoptotic pathways.
  • Potential carcinogens such as lead, antimony, and cobalt may also induce apoptosis.
  • Mechanisms involve complex signaling cascades.

Conclusions:

  • Understanding metal-induced apoptosis is vital for elucidating cancer mechanisms.
  • Certain metal species, like arsenic, show potential as chemotherapeutic agents.
  • Further research is needed to fully explore these connections.