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Updated: Aug 30, 2026

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
Published on: April 10, 2018
Over-expression of wild-type Securin leads to aneuploidy in human cells
Lina Christopoulou1, Jonathan D Moore, Chris Tyler-Smith
1Department of Biochemistry, CRC Chromosome Molecular Biology Group, University of Oxford, South Parks Road, OX1 3QU Oxford, UK.
Abstract:
Changes in gene expression and aneuploidy are both common features of cancers and under- or over-expression of single genes can cause aneuploidy. Securin, which is involved in chromatid separation, has transforming activity in vitro and is over-expressed in many tumours. We have used a GFP-based assay for chromosome loss in human cells to investigate the effects of over-expressing Securin. We find that over-expression causes a two-fold increase in chromosome loss rate and can thus be a direct cause of aneuploidy.
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