Related Experiment Video
Updated: Jul 16, 2026

07:04
Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
Published on: August 15, 2020
[Necrobacillosis and Lemierre's syndrome: case report]
F Valla1, C Berchiche, D Floret
1Département de pédiatrie, hôpital Edouard-Herriot, 69437 Lyon 03, France.
Summary
Necrobacillosis, a severe disease, and Lemierre's syndrome are often unrecognized. Prompt treatment with antibiotics can lead to favorable outcomes in pediatric cases.
Area of Science:
- Infectious Diseases
- Microbiology
- Pediatrics
Background:
- Necrobacillosis, caused by Fusobacterium necrophorum, and Lemierre's syndrome are infrequently recognized by clinicians.
- Lemierre's syndrome, a severe form of human necrobacillosis originating in the head, is characterized by potential complications.
Observation:
- A case report details a 5-year-old girl diagnosed with Lemierre's syndrome secondary to otitis media.
- The patient presented with symptoms indicative of severe infection and potential vascular involvement.
Findings:
- Necrobacillosis can manifest with peripheral abscesses, commonly affecting the lungs and liver.
- Internal jugular vein thrombosis is a frequent complication associated with Lemierre's syndrome.
Implications:
- Early recognition and diagnosis of necrobacillosis and Lemierre's syndrome are crucial for effective management.
- Prolonged antibiotic therapy, including metronidazole and amoxicillin, is effective in achieving favorable outcomes.
- This case highlights the importance of considering these rare but severe infections in pediatric patients with otitis media.
Related Concept Videos
Necrosis
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Rabies
Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Cellular Injury IV: Necrosis
Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
