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An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
Published on: February 10, 2014
In vivo behavior of three different injectable hydraulic calcium phosphate cements
D Apelt1, F Theiss, A O El-Warrak
1MSRU, Equine Department, Faculty of Veterinary Medicine, University of Zurich, Winterthurerstr. 260, CH-8057 Zurich, Switzerland.
Biomaterials
|December 4, 2003
Summary
Dicalcium phosphate dihydrate (DCPD) hydraulic cements show excellent biocompatibility and promote significant new bone formation in sheep bone defects. These DCPD cements were superior to apatite cement in bone regeneration over six months.
Area of Science:
- Biomaterials Science
- Orthopedic Research
- Tissue Engineering
Background:
- Bone defects pose significant clinical challenges.
- Biocompatible materials are crucial for bone regeneration.
- Dicalcium phosphate dihydrate (DCPD) and apatite cements are investigated for bone repair.
Purpose of the Study:
- To evaluate the in vivo biocompatibility and bone regeneration potential of two DCPD hydraulic cements compared to an apatite hydraulic cement.
- To assess the histological and histomorphometrical outcomes of cement implantation in sheep bone defects.
Main Methods:
- Cylindrical bone defects in sheep (epiphyseal and metaphyseal) were implanted with two DCPD cements and one apatite cement.
- Clinical and histological evaluations were performed at 2, 4, and 6 months post-implantation.
- Histomorphometry quantified new bone formation, fibrous tissue, and remaining cement.
Main Results:
- No macroscopic or microscopic signs of inflammation were observed for any cement type.
- All tested cements were gradually replaced by new bone tissue.
- The two DCPD cements demonstrated superior new bone formation and minimal cement remnants by 6 months compared to the apatite cement.
Conclusions:
- DCPD hydraulic cements exhibit excellent biocompatibility and osteoconductive properties.
- DCPD cements are effective in promoting bone regeneration in critical-sized bone defects.
- These findings support the potential clinical application of DCPD hydraulic cements in orthopedic and dental applications.
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