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Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart

Cristina Garcia-Frigola1, Yunqing Shi, Sylvia M Evans

  • 1Institute of Molecular Medicine and Department of Medicine, University of California at San Diego, La Jolla, CA 92093-0613, USA.

Gene Expression Patterns : GEP
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G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory organs,...