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Effect of poly-hydroxy aliphatic ester polymer type on amoxycillin release from cylindrical compacts
A Rosario Mollo1, Owen I Corrigan
1Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, Trinity College, University of Dublin, Ireland.
International Journal of Pharmaceutics
|December 4, 2003
Summary
Polymer molecular weight and composition significantly impact amoxycillin release from poly-lactic acid (PLA) and poly-lactic-co-glycolic acid (PLGA) systems. Amoxycillin inclusion also slows polymer degradation, suggesting potential binding interactions.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Poly-hydroxy aliphatic esters like PLA and PLGA are widely used in drug delivery.
- Amoxycillin is an amphoteric antibiotic requiring careful formulation for stability and release.
- Understanding drug-polymer interactions is crucial for optimizing drug delivery systems.
Purpose of the Study:
- To investigate the impact of PLA and PLGA molecular weight and composition on amoxycillin release and stability.
- To evaluate the effect of amoxycillin on the degradation kinetics of PLA and PLGA polymers.
- To elucidate the relationship between polymer properties, drug release, and polymer degradation.
Main Methods:
- Preparation of drug-free and amoxycillin-loaded PLA and PLGA cylindrical discs.
- Monitoring drug release profiles over time.
- Assessing polymer degradation through weight loss and molecular weight analysis.
- Kinetic modeling of polymer degradation.
Main Results:
- Drug release was faster with lower molecular weight and lower lactide content polymers.
- Higher lactide content polymers controlled drug release more effectively through degradation.
- Higher molecular weight polymers facilitated the release of a greater proportion of intact amoxycillin.
- Amoxycillin inclusion slowed polymer hydrolysis, with increased retardation observed in higher lactide content polymers.
Conclusions:
- Polymer molecular weight and lactide content are critical factors controlling amoxycillin release kinetics and stability.
- Amoxycillin or its degradation products may interact with PLA/PLGA, retarding polymer degradation.
- These findings provide insights for designing advanced drug delivery systems utilizing PLA and PLGA for amoxycillin.