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Quantitative evaluation of thrombosis by electrochemical methodology
Chun-Che Shih1, Chun-Ming Shih, Yea-Yang Su
1Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei 112, Taiwan.
Thrombosis Research
|December 4, 2003
Summary
This study developed an in situ method to monitor blood-metal reactions and thrombosis. Electrochemical monitoring successfully detected differences in passivation films on 316L stainless steel, aiding cardiovascular device development.
Area of Science:
- Biomaterials Science
- Electrochemistry
- Medical Device Engineering
Background:
- Electrochemical reactions between blood and metal electrodes have been studied since 1928.
- The current density induced during these reactions remains largely unknown.
- Thrombosis on cardiovascular devices is a critical clinical challenge.
Purpose of the Study:
- To develop an in situ continuous monitoring method for detecting thrombosis.
- To investigate the electrochemical behavior of oxidized 316L stainless steel in blood.
- To assess the influence of passivation film properties on thrombosis.
Main Methods:
- Deployment of an oxidized 316L stainless steel coil within an artery.
- In situ continuous electrochemical monitoring of current density.
- Analysis of current density stages related to thrombosis progression.
Main Results:
- Three distinct stages of current density were observed for 316L stainless steel with a polycrystalline oxide film.
- No significant current density was detected for 316L stainless steel with an amorphous oxide film.
- The monitoring method demonstrated sensitivity to passivation film characteristics.
Conclusions:
- The developed in situ electrochemical monitoring method is effective for detecting thrombosis.
- Passivation film properties significantly influence electrochemical reactions and thrombosis on 316L stainless steel.
- This method offers reliable information for controlling thrombosis on cardiovascular devices.