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Updated: Aug 30, 2026

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
Optical coherence tomographic observations before and after macular hole formation secondary to laser injury
Manabu Sasahara1, Sachiyo Noami, Masayo Takahashi
1Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Purpose:
To describe the ophthalmoscopic and optical coherence tomographically determined retinovitreous interface before and after the development of a macular hole secondary to an accidental laser injury.
Design:
Observational case report.
Methods:
Ophthalmoscopic and optical coherence tomography (OCT) findings in a 53-year-old man were evaluated before and after the macular hole formation secondary to a laser injury. Visual function was followed for 9 months after surgery.
Results:
A 53-year-old man sustained injury to his right eye by a Ti: Sapphire laser. On the following day, his corrected visual acuity was 0.3, and a small pigment epithelial atrophy was present in the right foveal area. No macular hole was detected by OCT and the retinovitreal interface was normal. Fifty-three days later, a full-thickness macular hole appeared, and no posterior vitreous detachment was detected by OCT. The hole was closed by surgery with final best-corrected visual acuity of 0.7.
Conclusions:
Macular holes can develop without visible traction on the retina and can occur long after retinal injury.
