Related Experiment Video
Updated: Aug 10, 2026

Quantifying the Heterogeneous Distribution of a Synaptic Protein in the Mouse Brain Using Immunofluorescence
Published on: January 29, 2019
Microtubule-associated protein 2 (MAP2) expression during synaptic plasticity in the guinea pig cochlea
Sabine Ladrech1, Marc Lenoir, Jérôme Ruel
1INSERM U583 et Universités Montpellier I et II, Physiopathologie et Thérapie des Déficits Sensoriels et Moteurs, 71, rue de Navacelles, 34090 Montpellier, France.
Abstract:
The expression of different isoforms of microtubule-associated proteins 2 (MAP2), including the low molecular weight form MAP2c present mainly in developing neurons, was investigated in the primary auditory neurons after alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) perfusion in the guinea pig cochlea. MAP2 expression appeared to be tightly regulated in the repairing neurons. Neurite regrowth seems to involve the MAP2c isoform. In cochlear neurons, mechanisms involved in the period of development might be reactivated after excitotoxic injury in the mature cochlea.

