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Related Experiment Videos

Glomerular filtration rate measured by using triphasic helical CT with a two-point Patlak plot technique.

Nils Hackstein1, Cornelia Wiegand, Wigbert Stefan Rau

  • 1Department of Diagnostic Radiology, Justus-Liebig Universität Giessen, Klinikstr 36, 35385 Giessen, Germany.

Radiology
|December 3, 2003
PubMed
Summary

The two-point Patlak plot accurately calculates glomerular filtration rate (GFR) using computed tomography (CT) in patients without kidney disorders. This CT method offers a reliable alternative for GFR measurement.

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Area of Science:

  • Radiology
  • Nephrology
  • Medical Imaging

Background:

  • Glomerular filtration rate (GFR) is a key indicator of kidney function.
  • Accurate GFR measurement is crucial for diagnosing and managing renal diseases.
  • Computed tomography (CT) offers potential for non-invasive GFR assessment.

Purpose of the Study:

  • To evaluate the accuracy of the two-point Patlak plot technique for calculating GFR.
  • To compare CT-based GFR measurements with a reference plasma clearance method.

Main Methods:

  • Fifty patients without acute renal disorder underwent a triphasic CT scan with iopromide contrast.
  • GFR was calculated using a two-point Patlak plot technique on CT data.
  • Plasma clearance of iopromide was determined from blood samples taken 3, 4, and 5 hours post-injection as a reference.

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Main Results:

  • GFR was successfully calculated in 48 patients using CT.
  • Mean GFR measured by CT (82 mL/min) closely correlated with plasma clearance (80 mL/min) (r=0.889).
  • The mean difference between the two methods was -1.2 mL/min, indicating good agreement.

Conclusions:

  • Minimally extended triphasic CT with a two-point Patlak plot accurately measures total GFR.
  • This CT-based method is suitable for patients without acute renal disorders.
  • The technique provides a reliable alternative for GFR assessment.