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Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
Urinary metabolites of nobiletin orally administered to rats
Takaaki Yasuda1, Yukako Yoshimura, Hisako Yabuki
1Department of Phytochemistry, Tohoku Pharmaceutical University, Sendai, Miyagi, Japan.
Chemical & Pharmaceutical Bulletin
|December 4, 2003
Abstract:
During the course of our systematic investigation of the metabolism of flavonoids, the polymethoxyflavone nobiletin, occurring in the fruits of Citrus depressa, was orally administered to rats. The urinary metabolites were separated and identified by three-dimensional HPLC equipped with a photodiode array detector and the structure was determined by spectroscopic methods to be 4'-hydroxy-3',5,6,7,8-pentamethoxyflavone (1).
