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Metabolic effects of growth hormone therapy in an Alström syndrome patient
Tsai-Sung Tai1, Shih-Yi Lin, Wayne Huey-Herng Sheu
1Division of Endocrinology and Metabolism, Chia-Yi Christian Hospital, Chia-Yi, Republic of China.
Aim:
To investigate the metabolic effects of recombinant human growth hormone (rhGH) in an Alström syndrome patient with growth hormone deficiency.
Methods:
A 15-year-old Alström syndrome boy with growth hormone deficiency received rhGH therapy for 1 year. Biochemical parameters, including hepatic enzyme levels, lipid profiles, and insulin sensitivity, were measured. Body composition analysis and computed tomography scans of the liver were performed.
Results:
After 1 year of rhGH treatment, body fat mass, fat infiltration in the liver, and serum lipid profiles had all decreased. Insulin sensitivity and acanthosis nigricans improved.
Conclusion:
rhGH therapy might have beneficial effects on body composition, liver fat content, lipid profiles, and insulin resistance in Alström syndrome patients, with improvement of the glucose homeostasis.
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