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[Sleep disorders during synucleopathies and taupathies].

I Arnulf1

  • 1Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris. arnulf@psl.ap-hop-paris.fr

Revue Neurologique
|December 4, 2003
PubMed
Summary

Patients with synucleopathy experience more REM sleep disorders than taupathy patients. These sleep disturbances may stem from non-dopaminergic pathway damage in the brain.

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Sleep medicine·2020

Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Neuropathology

Context:

  • Synucleinopathies and tauopathies are distinct neurodegenerative diseases.
  • Rapid eye movement (REM) sleep disorders are common in neurological conditions.
  • REM sleep behavior disorder (RBD) and sleep onset REM periods (SOREMPs) are key sleep abnormalities.

Purpose:

  • To investigate the prevalence of REM sleep disturbances in synucleinopathies versus tauopathies.
  • To explore the potential neurobiological underpinnings of these REM sleep abnormalities.

Summary:

  • Dissociative REM sleep states and SOREMPs are significantly more frequent in synucleinopathies compared to tauopathies.
  • RBD affects approximately one-third of patients with progressive supranuclear palsy (a taupathy).
  • Emerging evidence links these REM sleep issues to non-dopaminergic lesions, specifically affecting cholinergic neurons in the locus subcoeruleus and orexinergic neurons in the lateral hypothalamus.

Impact:

  • Highlights potential differences in disease mechanisms between synucleinopathies and tauopathies.
  • Suggests non-dopaminergic pathways are crucial in REM sleep regulation.
  • Provides insights for diagnosing and managing sleep disorders in neurodegenerative diseases.

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