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Updated: Aug 14, 2026

An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model
21:16

An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model

Published on: July 13, 2009

[Positive skin test and age]

W C Forte1, F F Júnior, W D Filho

  • 1Santa Casa de São Paulo, SP, Brazil.

Jornal De Pediatria
|December 4, 2003
PubMed

Insights

Allergen skin test reactivity in children with asthma and rhinitis increases with age. Positive responses are evident by 12 months and significantly increase from age 4 onwards.

Area of Science:

  • Pediatric Allergy and Immunology
  • Clinical Immunology

Background:

  • Asthma and rhinitis are common allergic conditions in children.
  • Assessing immediate hypersensitivity to allergens is crucial for diagnosis and management.

Purpose of the Study:

  • To evaluate the age-related positive skin test responses to common allergens in children with asthma and rhinitis.
  • To determine the age at which significant allergen sensitization becomes apparent.

Main Methods:

  • A cohort of 713 children with asthma and rhinitis were grouped by age (6 months to 15 years).
  • Skin prick tests were performed using fifteen diverse allergens.
  • Statistical analysis was conducted using the chi-square test.

Main Results:

  • Significant differences in skin test reactivity were observed across age groups.
  • Allergen sensitization was progressively acquired with increasing age.
  • Positive skin test reactivity was detectable as early as 12 months of age.

Conclusions:

  • Skin test reactivity to allergens develops gradually throughout childhood.
  • A significant increase in positive skin test responses is noted from 4 years of age onwards.
  • Early detection of allergen sensitization aids in managing pediatric allergic diseases.

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