Related Experiment Video
Updated: Aug 18, 2026

A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
[Chronic intestinal pseudo-obstruction in children - report of seven cases]
1Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Insights
This study details the clinical and histological features of a rare digestive tract obstruction syndrome in seven children. Early diagnosis and targeted therapies are crucial for improving patient outcomes and survival.
Area of Science:
- Pediatric Gastroenterology
- Histopathology
- Clinical Medicine
Background:
- Intestinal obstruction in children can be challenging to diagnose.
- Rare syndromes require careful consideration in differential diagnosis.
- Gastrointestinal (GI) symptoms necessitate thorough investigation.
Purpose of the Study:
- To describe clinical characteristics of children with a rare digestive tract obstruction.
- To detail histological abnormalities found on full-thickness intestinal biopsy.
- To emphasize the importance of differential diagnosis for non-mechanical obstructions.
Main Methods:
- Retrospective study of pediatric patients over ten years.
- Review of medical records for clinical and laboratorial data.
- Diagnosis based on integrated clinical, laboratorial, and histological findings.
Main Results:
- Seven pediatric cases with digestive tract obstruction were identified.
- Specific clinical presentations and histological findings were documented.
- The syndrome presented without identifiable mechanical causes.
Conclusions:
- This rare syndrome should be considered in pediatric patients with unexplained digestive tract obstruction.
- Accurate and early diagnosis is essential for effective management.
- Further research into less invasive diagnostic techniques and specific treatments is warranted to improve quality of life and survival.
Abstract:
OBJECTIVE: The purpose of this report is to describe the clinical characteristics and histological abnormalities on full-thickness intestinal biopsy in seven children from the Gastroenterology (GI) outpatient clinic. METHODS: A retrospective study of all patients who attended the GI outpatient clinic in the last ten years. The medical records of seven patients were reviewed, and all the relevant clinical data recorded. Diagnosis was based on clinical, laboratorial, and histological findings. CONCLUSION: Although this is a rare syndrome, the differential diagnosis shall be performed whenever the patient presents signs and symptoms of obstruction along the digestive tract with no association of any mechanical cause. Studies shall be encouraged regarding the precocious and accurate diagnosis, using less invasive techniques and specific therapeutics (both clinical and surgical), in order to improve life quality and extended survival of affected patients.
Related Concept Videos
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Pyloric Obstruction
Intestinal Obstruction I: Introduction
Intestinal Obstruction II: Pathophysiology
Diverticular Disease of the Colon
Appendicitis

