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[Diarrheal disease in hospitalized children - importance of the persistent diarrhea]
Insights
Persistent diarrhea (PD) is common in hospitalized Brazilian children, especially those under one year old from low-income families. PD significantly increases hospitalization duration and fatal outcomes, highlighting the need for better acute diarrhea management.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Diarrheal diseases remain a leading cause of mortality in young children globally.
- Persistent diarrhea (PD) is a severe form of diarrhea associated with increased morbidity and mortality.
- Understanding the epidemiological and clinical characteristics of PD is crucial for effective intervention.
Purpose of the Study:
- To analyze the epidemiological and clinical patterns of hospitalized children under 24 months with diarrhea.
- To determine the prevalence of persistent diarrhea (PD) in this population.
- To identify factors associated with PD and its outcomes.
Main Methods:
- A cross-sectional study of 300 children hospitalized with diarrhea in Recife, Northeast Brazil (July 1993-March 1994).
- Data collection included socio-demographic, clinical, and evolutive characteristics.
- Bidimensional analysis compared acute and persistent diarrhea groups; mortality proportions were compared.
Main Results:
- The majority of children were under one year old, from low-income families with poor living conditions.
- High incidence of early weaning (44.2%) and malnutrition (71.1% below 3rd percentile weight).
- PD occurred in 56.9% of cases, prolonged hospitalization, and was associated with a high fatality rate (72.9%).
Conclusions:
- Persistent diarrhea is highly prevalent among hospitalized children in this setting, particularly those under one year from disadvantaged backgrounds.
- PD significantly contributes to prolonged hospital stays and a disproportionately high number of deaths.
- Inadequate management of acute diarrhea is linked to the progression to persistent diarrhea and adverse outcomes.
Abstract:
OBJECTIVE: In this paper we aim at analyzing the epidemiological and clinical patterns of children with age below 24 months who were hospitalized with diarrhoea in order to determine the prevalence of persistent diarrhoea (PD). PATIENTS AND METHODS: 300 children with diarrhoea were studied at the General Hospital of Pediatrics - IMIP in Recife, Northeast Brazil, considering the period from July 1993 to March 1994. It was a cross-sectional study. The socio-demographic, clinical and evolutive characteristics of the sample were described. A bidimensional analysis was used to compare the groups with acute and persistent diarrhoea (PD) episodes. The proportion of deaths due to persistent diarrhoea was compared to the proportion of those due to acute diarrhoea. RESULTS: The majority of the children was younger than one year of age and come from low income families living in poor environmental and social conditions. At admission it was observed that the incidence of early weaning was high (44.2%); 71.1% of the children were below the third percentile for weight as compared with the NCHS curve. During the course of PD 33.2% of the children were hospitalized. Dysentery was detected in 52% of the cases. 106 children among the 246 observed (43.1%) recovered before the 14th day, while in 140 children (56.9%) diarrhoea persisted for two more weeks. PD contributed to extend the course of hospitalization and was associated with a higher proportion of fatal cases (72.9%). CONCLUSIONS: The majority of the children was younger than one year of age and come from low income families living in poor environmental and social conditions. PD frequency among the children who were hospitalized was high and accounted for a very high proportion of fatal cases. Inadequate management in the acute phase of diarrhoea was associated with the lengthening of the disease.
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