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[Bone marrow transplantation and cord blood transplantation in children]

Cláudio Galvão de Castro1, L J Gregianin, A L Brunetto

  • 1Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Jornal De Pediatria
|December 4, 2003
PubMed

Insights

Bone marrow transplantation offers a cure for children with specific neoplastic or immunological diseases. Understanding the procedure, including its steps and potential complications, is crucial for pediatricians to inform families.

Area of Science:

  • Pediatric Hematology/Oncology
  • Immunology
  • Transplantation Medicine

Background:

  • Bone marrow transplantation (BMT) is a critical therapeutic option for pediatric patients with various life-threatening conditions.
  • Advances in BMT have expanded its applicability, but it remains a complex procedure with potential risks.

Purpose of the Study:

  • To provide a comprehensive review of bone marrow transplantation in children.
  • To detail the indications, procedural steps, and potential complications associated with pediatric BMT.

Main Methods:

  • A literature review was conducted using Medline database.
  • Key aspects of BMT, including donor selection, cell sources, conditioning, and post-transplant events, were analyzed.

Main Results:

  • Indications for autologous, allogeneic, and syngeneic BMT are discussed, alongside donor selection and hematopoietic progenitor cell infusion.
  • Conditioning regimens, novel cell sources like cord blood, and common post-transplant complications (infections, graft-versus-host disease, organ-specific toxicities) are described.
  • Late effects and their impact on long-term quality of life are also addressed.

Conclusions:

  • While BMT may not guarantee a normal lifespan for all pediatric patients, it offers the sole curative potential for certain neoplastic and immunological diseases.
  • Pediatricians play a vital role in educating patients and families about BMT, its procedures, and associated outcomes.

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