[T-cell subsets and intercellular adhesion molecule-1 in human allergic nasal mucosa]

We performed an immunohistological study of T-cell subsets and intercellular adhesion molecules in allergic and non-allergic nasal mucosa. In allergic mucosa, the number of CD4 positive cells tended to dominate that of CD8 positive cells. CD8 positive cells were detected randomly in all regions of the mucosa, whereas CD4 positive cells tended to be clustered in the superficial portion of the lamina propria. Furthermore, the number of CD4 positive cells correlated with the intensity of ICAM-1 expression, especially in the superficial portion of the lamina propria.