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The EGF-TM7 family: a postgenomic view
Mark J Kwakkenbos1, Else N Kop, Martin Stacey
1Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, G1-106, PO Box 22700, 1100 DE, Amsterdam, The Netherlands.
Immunogenetics
|December 3, 2003
Summary
The EGF-TM7 receptor family, primarily on immune cells, has unique structures and binds ligands like CD55. The CD97 receptor plays a role in leukocyte migration, highlighting this evolving receptor group.
Area of Science:
- Immunology
- Cell Biology
- Genomics
Background:
- Mammalian cell receptor repertoire elucidated by genome projects.
- EGF-TM7 receptors are a unique class B seven-span transmembrane (TM7) receptor family.
- Predominantly expressed on immune cells.
Purpose of the Study:
- Discuss current information on the EGF-TM7 receptor family.
- Highlight unique molecular structure and ligand-binding properties.
- Review the role of EGF-TM7 receptors in cellular functions.
Main Methods:
- Analysis of completed human and mouse genome projects.
- Review of existing literature on EGF-TM7 receptor structure and function.
- Inclusion of recent in vivo studies on specific receptors like CD97.
Main Results:
- EGF-TM7 receptors are heterodimers with distinct extracellular domains.
- Interact with ligands such as CD55 and chondroitin sulfate.
- CD97 receptor is involved in leukocyte migration.
Conclusions:
- EGF-TM7 receptor family exhibits unique characteristics within the TM7 superfamily.
- Ongoing evolution of the receptor family is suggested by gene variations and specific receptor properties.
- Further research is warranted to fully understand this intriguing receptor family.