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Successful treatment of axillary hyperhidrosis with very low doses of botulinum toxin B: a pilot study

Martin J Hecht1, Frank Birklein, Martin Winterholler

  • 1Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany. martin.hecht@neuro.imed.uni-erlangen.de

Archives of Dermatological Research
|December 3, 2003
PubMed
Abstract

No abstract available in PubMed .

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...