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odd-skipped homologs function during gut development in C. elegans.

Martin S Buckley1, Johnnie Chau, Pamela E Hoppe

  • 1Department of Biology, Saint Louis University, MO 63103-2010, USA.

Development Genes and Evolution
|December 3, 2003
PubMed
Summary
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The odd-skipped (odd) gene family, including odd-1 and odd-2 in C. elegans, plays crucial roles in gut development. Their functions suggest gut specification is an ancestral role for this gene family across metazoans.

Area of Science:

  • Developmental biology
  • Evolutionary genetics
  • Molecular biology

Background:

  • The odd-skipped (odd) gene family encodes C2H2 zinc finger proteins found across metazoans.
  • While initially identified in Drosophila segmentation, odd gene homologs exhibit complex expression patterns suggesting broader roles.

Purpose of the Study:

  • To investigate the evolutionary history of the odd gene family.
  • To characterize the functions of two C. elegans homologs, odd-1 and odd-2, in gut development.

Main Methods:

  • Sequence comparisons of odd homologs across species (insects, mammals, nematodes).
  • RNA interference (RNAi) to analyze gene function in C. elegans.
  • GFP-reporter assays to determine gene expression patterns.

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Main Results:

  • Sequence data suggest two ancestral metazoan odd paralogs, with duplications occurring post-arthropod/chordate split.
  • odd-1 and odd-2 exhibit essential and distinct roles in C. elegans gut development.
  • Both genes are specifically expressed in the developing intestine and surrounding cells.

Conclusions:

  • The findings support gut specification as an ancestral function for the odd gene family.
  • odd-1 and odd-2 function similarly to Drosophila homologs bowel and drumstick.
  • Evolutionary analysis reveals gene duplication events shaping the odd family.