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Physics of amorphous solids.

Lori R Hilden1, Kenneth R Morris

  • 1Bristol-Myers Squibb Company, PO Box 191, New Brunswick, New Jersey 08903-0191, USA.

Journal of Pharmaceutical Sciences
|December 4, 2003
PubMed
Summary
This summary is machine-generated.

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The physical state of drug solids, whether crystalline or amorphous, significantly impacts their properties. This review covers the physics of preparing and storing amorphous solids, including glass transition and relaxation theories.

Area of Science:

  • Pharmaceutical Sciences
  • Physical Chemistry
  • Materials Science

Background:

  • The solid-state form of a dosage affects its physical and chemical characteristics.
  • Understanding amorphous versus crystalline states is crucial for drug development.

Purpose of the Study:

  • To review the physics of preparing and storing amorphous solid dosage forms.
  • To discuss theories of glass transition and relaxation processes relevant to amorphous solids.

Main Methods:

  • Literature review of physical principles.
  • Analysis of common theories on glass transition.
  • Examination of relaxation processes in amorphous systems.

Main Results:

  • Amorphous solids present unique challenges in preparation and storage.

Related Experiment Videos

  • Glass transition and relaxation dynamics are key to understanding amorphous solid behavior.
  • Theoretical frameworks exist to explain these phenomena.

    • Conclusions:

    • The physical state (amorphous vs. crystalline) is a critical determinant of solid-state properties.
    • Knowledge of amorphous solid physics is essential for stable and effective dosage forms.