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Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines
Liang Fang1, Sachihiko Numajiri, Daisuke Kobayashi
1Faculty of Pharmaceutial Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.
Journal of Pharmaceutical Sciences
|December 4, 2003
Abstract:
The preparation of mefenamic acid (MH)-alkanolamine (propanolamine, diethanolamine, triethanolamine) complexes was attempted to increase the transdermal flux of MH. Differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray crystallographic studies demonstrated that MH and each alkanolamine formed an ion pair complex. The series of amine complexes had a lower melting point and higher solubility in water compared with pure MH.