Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ischaemia-reperfusion is an event triggered by immune complexes and complement.

R K Chan1, S I Ibrahim, N Verna

  • 1Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. hhechtman@partners.org

The British Journal of Surgery
|December 4, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determination of total body water and solids with isotopes.

Science (New York, N.Y.)·2010
Same author

The anemia of thermal burns.

Annals of surgery·2010
Same author

Papillary adenocarcinoma of head of pancreas, with metastases to common bile duct and lung.

The New England journal of medicine·2010
Same author

Effect of iodine on the thyroid gland in Graves' disease when given in conjunction with thiouracil; a two-action theory of iodine.

The Journal of clinical investigation·2010
Same author

Toxic manifestations of thiouracil therapy.

Journal of the American Medical Association·2010
Same author

Transdiaphragmatic resection of the vagus nerves for peptic ulcer.

The New England journal of medicine·2010
Same journal

Trimester-Specific Safety of Laparoscopic versus Open Abdominal Surgery During Pregnancy: A Systematic Review and Meta-analysis.

The British journal of surgery·2026
Same journal

The Gut Microbiome in Surgical Oncology: Mechanisms, Perioperative Outcomes, and Therapeutic Opportunities.

The British journal of surgery·2026
Same journal

Patient-led, home-based follow-up for colorectal cancer: the DISTANCE multicentre stepped-wedge cluster-randomised trial.

The British journal of surgery·2026
Same journal

Correction to: Reduced secretory efficiency in parathyroid carcinoma: diagnostic value of the PTH-to-tumour-volume ratio.

The British journal of surgery·2026
Same journal

Global disparities in hepatocellular carcinoma outcomes: multicentre study.

The British journal of surgery·2026
Same journal

Surgical Outcomes from Nationwide Implementation of the International Best-Practice for Locally Advanced Pancreatic Cancer (PREOPANC-4) study.

The British journal of surgery·2026
See all related articles

Reperfusion injury, a clinical challenge, may be driven by immune responses rather than free radicals. New evidence highlights complement activation and immune complexes as key mediators.

Area of Science:

  • Immunology
  • Pathophysiology
  • Medical Science

Background:

  • Reperfusion injury presents a significant clinical challenge with limited therapeutic options.
  • Previous research focusing on oxygen free radicals and neutrophils has yielded no successful clinical treatments.
  • Understanding the underlying mechanisms of reperfusion injury is crucial for developing effective therapies.

Purpose of the Study:

  • To review recent clinical and preclinical findings on mitigating reperfusion injury.
  • To identify novel therapeutic targets and strategies for managing reperfusion injury.
  • To synthesize current evidence on the pathophysiology of reperfusion injury.

Main Methods:

  • Comprehensive literature review of MEDLINE database (1966-2003).

Related Experiment Videos

  • Inclusion of studies without language restrictions.
  • Analysis of both clinical and preclinical data on reperfusion injury.

    • Main Results:

    • Emerging evidence implicates the complement system and immune complexes in reperfusion injury.
    • Ischemia may induce cellular changes, leading to neoantigen expression.
    • Natural IgM antibodies can be trapped, initiating complement activation.

    Conclusions:

    • Complement activation and immune complexes are critical in mediating reperfusion injury.
    • Formation of the membrane attack complex and mast cell degranulation are key terminal events.
    • This understanding offers new avenues for therapeutic intervention in reperfusion injury.