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Bone diseases in children receiving growth hormone
Mahmoud Smida1, Hbib Nouri, Hajer Kandara
1Department of Paediatric Orthopaedics, Tunis Children's Hospital (Hôpital d'Enfants de Tunis), Bab Saadoun 1007 Tunis, Tunisia. mahmoud.smida@rns.tn
Acta Orthopaedica Belgica
|December 3, 2003
Summary
Growth hormone (GH) therapy for children with short stature may be linked to bone disorders like avascular necrosis and slipped capital femoral epiphysis (SCFE). Further research is needed to understand GH
Area of Science:
- Pediatric Endocrinology
- Pediatric Orthopedics
- Growth Hormone Therapy
Background:
- Short stature in children is often treated with growth hormone (GH) supplementation.
- Growth hormone deficiency requires careful management and monitoring for potential complications.
Observation:
- Two adolescent patients with short stature and confirmed GH deficiency experienced bone complications during GH therapy.
- Complications included avascular necrosis of the femoral head, scoliosis, and slipped capital femoral epiphysis (SCFE).
Findings:
- Avascular necrosis and SCFE were diagnosed in patients undergoing GH treatment.
- The specific role of GH in the development of these bone disorders remains unclear.
Implications:
- These cases highlight the need for vigilance regarding potential orthopedic complications in children receiving GH therapy.
- Further investigation is crucial to elucidate the relationship between GH supplementation and bone pathologies in pediatric patients.