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[Biochemical pharmacological effects of lurongjing on young or old mice]
1First Affiliated Hospital, Jilin University, Changchun 130021.
Objective:
To investigate the effect of Lurongjing (LRJ) on young or old mice.
Methods:
In vivo monoamine oxidase (MAO) and superoxide dismutase(SOD) activities, the contents of monoamines(5-HT, NE, DA), malondialdehyde (MDA), RNA and protein, and the incorporations of [3H] Uridine into RNA and [3H] Leucine into protein in liver tissue were measured.
Results:
The inhibition of MAO-B activity and the increase of monoamines(5-HT, DA) level, the increase of RNA and protein level, and the incorporations of [3H] Uridine into RNA and [3H] Leucine into protein in liver tissue, the enhancement of SOD activity and the decrease of MDA content in brain and liver tissues were selectively observed in old mice(24 months) than in young mice(1 month) by LRJ (i.g., 4.0 g/kg) administrated orally for 10 successive days.
Conclusion:
LRJ exhibits some anti-aging effect in old mice.