Related Experiment Video
Updated: Aug 11, 2026
05:45
Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
Fidarestat. Sanwa Kagaku/NC Curex/Sankyo
1University of Pittsburgh School of Medicine, Diabetes Institute, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA. ngiann1@pitt.edu
Current Opinion in Investigational Drugs (London, England : 2000)
|December 3, 2003
Summary
Fidarestat, an aldose reductase inhibitor, is being developed to treat diabetic neuropathy. This novel therapeutic agent targets a key pathway implicated in nerve damage associated with diabetes.
Area of Science:
- Pharmacology
- Diabetology
- Neurology
Background:
- Diabetic neuropathy is a common complication of diabetes mellitus.
- Aldose reductase plays a role in the pathogenesis of diabetic neuropathy by promoting the accumulation of sorbitol in nerve tissues.
- Inhibiting aldose reductase may offer a therapeutic strategy for preventing or reversing nerve damage.
Purpose of the Study:
- To evaluate the efficacy and safety of fidarestat for the potential treatment of diabetic neuropathy.
Main Methods:
- Fidarestat is an aldose reductase inhibitor.
- Co-developed by Sanwa Kagaku, NC Curex, and Sankyo.
- Undergoing development for diabetic neuropathy treatment.
Main Results:
- Fidarestat demonstrated potential in preclinical and clinical studies (details not provided in abstract).
Conclusions:
- Fidarestat represents a promising therapeutic candidate for diabetic neuropathy.
- Further clinical development is warranted to confirm its efficacy and safety profile.
Related Concept Videos
01:28Hospitals-I
Hospitals offer medical and surgical care to the sick and injured, along with accommodation while they recover. At the same time, they also provide outpatient, emergency, psychiatric, and rehabilitation services to meet various community needs. In addition to providing medical care, hospitals also act as hubs for medical research and training. Hospitals use clinical procedures and evidence-based practice standards to deliver patient care. To deliver safe and efficient care, a nurse must stay up...
00:59Hospitals-II
Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in hospitals have...
Nurses that work in hospitals have...
01:24Data Reporting and Recording
Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
01:17Healthcare Agencies II
There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources, and lay...
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources, and lay...
01:26Curing Methods
Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
01:19Personal Choice and Fate Attributions
Some individuals interpret life events as a consequence of their personal choices and actions, while others believe that outcomes are dictated by fate or destiny. This divergence in perspective has been examined in psychological and cross-cultural studies, particularly in relation to religious faith and cultural beliefs about causality.Fate and Personal ResponsibilityPeople who emphasize personal responsibility view events as direct consequences of their decisions. For instance, breaking a leg...