Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

More for less in structural genomics.

A Heger1, L Holm

  • 1Institute of Biotechnology, PO Box 56, 00014 University of Helsinki, Finland.

Journal of Structural and Functional Genomics
|December 3, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Crust Composition and the Shallow Heat Source in KS 1731-260.

Physical review letters·2025
Same author

Lower basal and postprandial muscle protein synthesis after 2 weeks single-leg immobilization in older men: No protective effect of anti-inflammatory medication.

Physiological reports·2024
Same author

Advancement of Photospheric Radius Expansion and Clocked Type-I X-Ray Burst Models with the New ^{22}Mg(α,p)^{25}Al Reaction Rate Determined at the Gamow Energy.

Physical review letters·2021
Same author

New ^{59}Fe Stellar Decay Rate with Implications for the ^{60}Fe Radioactivity in Massive Stars.

Physical review letters·2021
Same author

Diabetes and COVID-19: psychosocial consequences of the COVID-19 pandemic in people with diabetes in Denmark-what characterizes people with high levels of COVID-19-related worries?

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

Fatal attack on a pedestrian by an escaped circus elephant.

Forensic science international·2019
Same journal

Protein sequence-similarity search acceleration using a heuristic algorithm with a sensitive matrix.

Journal of structural and functional genomics·2017
Same journal

Toward the next step in G protein-coupled receptor research: a knowledge-driven analysis for the next potential targets in drug discovery.

Journal of structural and functional genomics·2017
Same journal

Special issue: big data analyses in structural and functional genomics.

Journal of structural and functional genomics·2017
Same journal

Classification of ligand molecules in PDB with graph match-based structural superposition.

Journal of structural and functional genomics·2016
Same journal

VaProS: a database-integration approach for protein/genome information retrieval.

Journal of structural and functional genomics·2016
Same journal

NLDB: a database for 3D protein-ligand interactions in enzymatic reactions.

Journal of structural and functional genomics·2016
See all related articles

A new MaxFlow algorithm accurately aligns distantly related proteins, enabling 3D model generation for structural genomics. This advances protein sequence similarity analysis and target prioritization.

Area of Science:

  • Structural biology
  • Bioinformatics

Background:

  • Structural genomics aims to determine protein structures for all sequences.
  • Current methods struggle with aligning distantly related proteins (low sequence identity).

Purpose of the Study:

  • To develop a novel algorithm for accurate protein sequence alignment in the low-similarity twilight zone.
  • To improve 3D model generation and target prioritization in structural genomics.

Main Methods:

  • Development of a transitive alignment algorithm named MaxFlow.
  • Application of MaxFlow to identify conserved motifs between proteins with low sequence identity.
  • Utilizing MaxFlow scores for template prediction in protein superfamilies.

Main Results:

Related Experiment Videos

  • MaxFlow achieves accurate alignments for proteins below 20% sequence identity.
  • The algorithm reliably identifies conserved core motifs, even for indirect PSI-Blast neighbors.
  • Enables 3D model generation for entire superfamilies from limited structural templates.

    • Conclusions:

    • MaxFlow significantly enhances the ability to model proteins with distant homology.
    • Novel strategies for target prioritization in structural genomics are proposed.
    • The findings have economic implications for advancing structural genomics.